Hematology Panels
Because single-cell insights are critical to determining the source of resistance, response, and relapse
The complexity of cancer is vast, and it is critical to measure the network of biological interactions accurately and minimize inferences. With Mission Bio’s hematology panels, you can simultaneously analyze DNA mutations and protein expression, to discover clonal networks otherwise obfuscated by bulk methods done in parallel. By connecting genotype to phenotype at the single-cell level, you can gain comprehensive insights into disease progression, development of resistance, and minimal residual disease (MRD).
Why Single Cell for Hematologic Malignancy Applications?
For hematologic malignancies, simultaneous DNA and protein analysis from the same cell can resolve the zygosity of mutations, determine if mutations co-occur or are mutually exclusive, and correlate that to immunophenotypes. With these insights, phylogenetic trees can be reconstructed to determine the order of acquisition of these mutations. Fish plots show how clonal architecture changes throughout the course of treatment. And monitoring during remission poses great promise for sensitive MRD detection.
It is time to get a holistic view of cancer
Track clonal evolution and reconstruct phylogenetic trees
Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics
Dr. Koichi Takahashi, MD Anderson Cancer Center
Reveal therapy resistance mechanisms through course of treatment
Clonal selection with Ras pathway activation mediates secondary clinical resistance to selective FLT3 inhibition in AML
Dr. Cathy Smith, Dr. Alexander Perl, UCSF, UPenn
Monitor disease during remission to track MRD
Single-cell mutational profiling enhances the clinical evaluation of AML MRD
Dr. Ravi Majeti, Stanford
Hematology Panels
Order predesigned hematology panels or customize any panel with your own targets
Select panel content relevant to your specific sequencing applications to understand the nature of the disease and potential mechanisms of therapeutic resistance. We offer several catalog targeted panels based on public databases and actionable clinical targets.
Available DNA Hematology Panels
Ready-to-Ship
Tapestri Single-cell DNA Catalog Panels
Predesigned and ready-to-ship hematology panels covering the most commonly implicated genes in hematologic malignancies. Wet lab-tested to assure performance.
NEW: Tapestri Single-cell DNA Published Panels
Predesigned and ready-to-ship hematology panels designed by leading researchers of hematologic malignancies. Featured in peer-reviewed publications from leading research institutes.
Build-to-Order
Tapestri Single-cell DNA Virtual Design Panels
Predesigned and build-to-order panels for additional indications in hematologic malignancies.
Tapestri Single-cell DNA Custom Panels
Fully customizable hematology panels for maximum flexibility. Easily order a custom panel using Tapestri Designer.
Available Protein Hematology Panels
Concurrently measure proteins by ordering the ready-to-ship TotalSeq™-D Heme Oncology Cocktail or by configuring your own antibody cocktail from a growing catalog of pre-optimized antibody oligonucleotide conjugates.
Hear from a hematological pathologist on how single-cell multi-omics can transform cell therapies for leukemias.
Katherine D. Cummins, MD, FRACP, FRCPA, University of Pennsylvania
DNA Is Our Foundation
Providing cancer researchers with the only single-cell multi-omics solution that simultaneously detects SNV, CNV, and protein data from the same cell.
Single-cell Genomics (DNA)
SNV
Detect rare clonal populations and identify co-occurrence and zygosity.
SNV + CNV
Characterize genomic heterogeneity using a single comprehensive platform.
Single-cell Multi-omics (DNA+)
DNA + Protein
Gain a true multi-omics picture from genotype to phenotype.
Featured Resources
Molecular Analysis of Acute Myeloid Leukemia in Morphologic Remission
Ready to learn more?
Use Tapestri Designer to design a custom panel tailored to your needs.