On The Drop
Welcome to On The Drop, Mission Bio’s official podcast dedicated to bringing forth leading conversations in cancer research leveraging advances in single-cell multi-omics. Start listening below!
Risk of Secondary Tumors after CAR T Therapy: A Discussion with Dr. Ash Alizadeh and Dr. Mark Hamilton
Recently published in the New England Journal of Medicine, researchers from Stanford University found that comprehensive genetic characterization of T-cell lymphomas after CAR T-cell therapy remains essential for understanding the risk of potential tumors with this therapy. Our own Dr. Todd Druley sat down with two of the publication's authors, Dr. Ash Alizadeh and Dr. Mark Hamilton, to discuss their findings.
From Cells to Cures: Panel Discussion on Advancing Clonal Profiling in Leukemia & Myeloma With Single-Cell Multiomics
In this roundtable, hear from Hervé Avet-Loiseau, MD, PhD, Head of the Laboratory for Genomics in Myeloma, University Cancer Center of Toulouse, Felipe Prósper, MD, PhD, Co-Director of Hematology and Cell Therapy, Clínica Universidad de Navarra, and Cedric Dos Santos, PhD, Director AML/MDS/MM, Translational Medicine, Genentech, as they discuss real-world studies enabling clonal surveillance for precision therapy insights and measurable residual disease surveillance, bridging research and drug development to explore the clinical impact and future horizons of single-cell analysis in AML and MM diagnostics & therapies.
The Hills and Valleys of Precision Medicine with Aaron Llanso
In this episode, we sit down with Senior Director of Clinical Applications, Aaron Llanso. Aaron discusses his untraditional career path, his personal experience with cancer, and how truly impactful the Tapestri scMRD Assay for AML can be for a patient's journey.
The Hills and Valleys of Precision Medicine with Director of Product Development Nicole Ovadia
In our latest installment in our Hills and Valleys of Precision Medicine series, Ania Wronski, PhD, chats with our Director of Product Development Nicole Ovadia, PhD, about our Tapestri Single-cell Multi-omics MRD (scMRD) Assay for AML.
The Hills and Valleys of Precision Medicine with Mission Bio's CMO, Dr. Todd Druley
In this episode, we sit down with Mission Bio's Chief Medical Officer, Dr. Todd Druley. Todd discusses his background in pediatric oncology and molecular genetics, why he decided to join Mission Bio, and how we're tackling some of the biggest challenges in precision medicine.
Reflections from Mission Bio’s CEO, Yan Zhang
In this episode, we sit down with Mission Bio’s CEO, Yan Zhang, to discuss her first nine months at the helm of Mission Bio. Yan chats with about her background in the life sciences, her decision to join Mission Bio, and the challenges she has faced on her journey to becoming a CEO.
Exploring Somatic Genetic Rescue and Pediatric MDS with Sushree Sahoo
In this Researcher Spotlight, we chat with Sushree Sahoo from the St. Jude Children’s Research Hospital in Memphis, Tennessee. Sushree specializes in translational, molecular genetics, and is passionate about uncovering the underlying mechanisms of diseases like cancer. We discuss somatic genetic rescue in her paper, “Clinical evolution, genetic landscape, and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes”
A Look into the Women of Mission Bio (Womo) (Samantha Mason)
This week, we’re excited to explore the origins of Women of Mission Bio Group (WOMO) and are delighted to speak with one of it’s founders Samantha Mason, Mission Bio’s Director of Software Products. Samantha founded WOMO as a safe space for women, by women, to come together from across the organization where they can openly discuss topics pertaining to women, network, and providing leadership guidance during times of adversity.
Investigating the Roots of Leukemia and AML with Linde Miles of Memorial Sloan Kettering Cancer Center
In this Researcher Spotlight, we speak with Linde Miles from the Memorial Sloan Kettering Cancer Center, New York. Linde has participated in the largest study ever to investigate the genetic roots of Leukemia at the single-cell level. Last October, she co-authored a paper in Nature titled "Single-cell mutation analysis of clonal evolution in myeloid malignancies".
Discovering the Cancer-like Mechanism Of Cerebral Cavernous Malformations (Doug Marchuk & Daniel Snellings)
In this Researcher Spotlight, we speak with Doug Marchuk and Daniel Snellings from the Duke University School of Medicine. Doug and Daniel’s work centers on the genetics that underlies cardiovascular diseases. They recently published a paper in Nature entitled, PIK3CA and CCM Mutations Fuel Cavernomas Through a Cancer-Like Mechanism.
Advancing Therapeutics with Mission Bio’s Pharma Assay Development (PAD) (Harsha Kuvari)
Last month, Mission Bio launched it’s PAD (Pharma Assay Development) solutions. In this weeks episode, Harsha Kavuri tackles some of the exciting benefits and capabilities PAD may be used in bringing effective therapies to cancer patients.
Dissecting Acute Myeloid Leukemia One Cell at a Time (Ross Levine)
In this Researcher Spotlight, we speak with Dr. Ross Levine from Memorial Sloan Kettering. Dr. Levine aims to better understand the genetic basis of myeloid malignancies and discusses his journey in hematological oncology and how using single-cell analysis has furthered advancements in his research.
Pairing CRISPR and Single-cell Analysis to Model Cancer (Ilaria Iacobucci)
In this Researcher Spotlight, we chat with Ilaria Iacobucci, PhD from the St. Jude Children’s Research Hospital about pairing single-cell analysis with CRISPR, women in science, and pandemic woes.
