Table 2: Attribute considerations for developing a successful cell and gene therapy assay
Vector copy number (VCN)
Unlike bulk assays that report a misleading population average, our single-cell cell and gene therapy assays can quantify the precise number of vector copies in thousands of individual cells. This reveals the true distribution of your therapeutic dose, allowing you to identify and eliminate unsafe cell populations with dangerously high copy numbers or ineffective cells with none at all, providing a far more accurate measure of your therapy products potency and safety.
Integrated vs Episomal
Determine the durability and mechanism of your cell and gene therapy by distinguishing whether your vector is integrated into the host genome or exists transiently as episomal DNA. Our single-cell cell and gene therapy assays can be designed to provide this critical information, clarifying the long-term therapeutic potential and stability of your cell and gene therapy without the need for laborious cell culturing and cloning.
Integrated vs Episomal
Determine the durability and mechanism of your cell and gene therapy by distinguishing whether your vector is integrated into the host genome or exists transiently as episomal DNA. Our single-cell cell and gene therapy assays can be designed to provide this critical information, clarifying the long-term therapeutic potential and stability of your cell and gene therapy without the need for laborious cell culturing and cloning.
Integrated vs Episomal
Determine the durability and mechanism of your cell and gene therapy by distinguishing whether your vector is integrated into the host genome or exists transiently as episomal DNA. Our single-cell cell and gene therapy assays can be designed to provide this critical information, clarifying the long-term therapeutic potential and stability of your cell and gene therapy without the need for laborious cell culturing and cloning.
Integrated vs Episomal
Determine the durability and mechanism of your cell and gene therapy by distinguishing whether your vector is integrated into the host genome or exists transiently as episomal DNA. Our single-cell cell and gene therapy assays can be designed to provide this critical information, clarifying the long-term therapeutic potential and stability of your cell and gene therapy without the need for laborious cell culturing and cloning.
Integrated vs Episomal
Determine the durability and mechanism of your cell and gene therapy by distinguishing whether your vector is integrated into the host genome or exists transiently as episomal DNA. Our single-cell cell and gene therapy assays can be designed to provide this critical information, clarifying the long-term therapeutic potential and stability of your cell and gene therapy without the need for laborious cell culturing and cloning.
Integrated vs Episomal
Determine the durability and mechanism of your cell and gene therapy by distinguishing whether your vector is integrated into the host genome or exists transiently as episomal DNA. Our single-cell cell and gene therapy assays can be designed to provide this critical information, clarifying the long-term therapeutic potential and stability of your cell and gene therapy without the need for laborious cell culturing and cloning.
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See the data
Details of Each Panel
Genome integrity is essential for predicting therapeutic safety and patient outcomes, whether dealing with cell-based therapies or analyzing heterogeneous tumors. Traditional methods for assessing genome stability are often limited by low throughput or time-consuming clonal outgrowth processes.
Now, with Mission Bio’s Tapestri Genome Integrity Assay, comprehensively analyze genome-wide copy number variations (CNVs) across thousands of cells in a single assay. This powerful assay enables you to evaluate genome stability within cell therapies and detect aneuploidy in cancer clones with unmatched resolution and scale.
Our streamlined multiple myeloma workflow allows you to multiplex bone marrow samples on the Tapestri Platform, sequence the libraries on an NGS platform, and then easily analyze the results using the Tapestri Multiple Myeloma Software. The Solution can integrate SNVs, focal CNAs, genome-wide CNVs, V(D)J clonotype, and immunophenotype.
Comprehensive Support Across the Pharma Workflow
Scope Project
Panel &
Assay Design
Wet Lab
Data Analysis
Long-term
Pipeline
Support
Panel &
Assay Design
Create Clear Reports To Easily Interpret Results
Zygosity of On-target Edits
The 10 most frequent variants and the percentage of cells that contain the variant on both alleles (biallelic), one allele (monoallelic), and not at all (wild type, WT). The variant name in the format of “chromosome:position:reference bases/alternative bases” are labeled on the x-axis. For multiplex experiments, the target group may be selected from the dropdown menu in the report.
Zygosity of On-target Edits
The 10 most frequent variants and the percentage of cells that contain the variant on both alleles (biallelic), one allele (monoallelic), and not at all (wild type, WT). The variant name in the format of “chromosome:position:reference bases/alternative bases” are labeled on the x-axis. For multiplex experiments, the target group may be selected from the dropdown menu in the report.
Zygosity of On-target Edits
The 10 most frequent variants and the percentage of cells that contain the variant on both alleles (biallelic), one allele (monoallelic), and not at all (wild type, WT). The variant name in the format of “chromosome:position:reference bases/alternative bases” are labeled on the x-axis. For multiplex experiments, the target group may be selected from the dropdown menu in the report.
Zygosity of On-target Edits
The 10 most frequent variants and the percentage of cells that contain the variant on both alleles (biallelic), one allele (monoallelic), and not at all (wild type, WT). The variant name in the format of “chromosome:position:reference bases/alternative bases” are labeled on the x-axis. For multiplex experiments, the target group may be selected from the dropdown menu in the report.
8M
Cells analyzed on
Tapestri in-house
15+
Novel custom assays
developed and
transfered to GMP
100+
Publications world-wide from
leading KOLs
45+
PAD and IND-enabling projects with Top Global
Pharma partners
Developing Custom Assays for Leading Companies
Genome Integrity Characterization of Genome-Edited Cell Therapies for Safety Assessment
Robust Characterization of Cell and Gene Therapies with Single-cell Analysis
Watch our video on Tapestri for Cell and Gene Therapies.
Robust Characterization of Cell and Gene Therapies with Single-cell Analysis
Watch our video on Tapestri for Cell and Gene Therapies.
PEER SCIENCE
Doug Marchuk and Daniel Snellings from the Duke University School of Medicine study the genetics of cerebral cavernous malformations using single-cell DNA sequencing
Ross Levine at MSKCC discusses using single-cell analysis to elucidate clonal evolution, including delineating which mutations occur in the same clone(s), accurately measuring clonal complexity, and definitively determining the order of mutations
Jan Cools at the VIB Center for Cancer Biology applies high-throughput single-cell DNA sequencing to determine the clonal heterogeneity in acute lymphoblastic leukemia patients at diagnosis and monitor the clonal evolution during treatment
Clonal evolution
Track clonal evolution and reconstruct phylogenetic trees
Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics
Clonal evolution
Track clonal evolution and reconstruct phylogenetic trees
Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics
Clonal evolution
Reveal therapy resistance mechanisms through course of treatment
Clonal selection with Ras pathway activation mediates secondary clinical resistance to selective FLT3 inhibition in AML
Dr. Cathy Smith, Dr. Alexander Perl, UCSF, UPenn
Clonal evolution
Track clonal evolution and reconstruct phylogenetic trees
Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics
Clonal evolution
Track clonal evolution and reconstruct phylogenetic trees
Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics
Clonal evolution
Reveal therapy resistance mechanisms through course of treatment
Clonal selection with Ras pathway activation mediates secondary clinical resistance to selective FLT3 inhibition in AML
Dr. Cathy Smith, Dr. Alexander Perl, UCSF, UPenn
Case Study
EPI-Clone study: Clonal tracing with somatic epimutations reveals dynamics of blood ageing.
(Adapted from Scherer M. et al., Nature 643, 478–487 (2025))
- CpG analysis revealed age-dependent mutations, identifying both known and newly detected CH (clonal hematopoiesis) mutations.
- Static CpG UMAPs overlaid with clonal structures showed methylation-based clustering aligned with known CH mutations.
- Lineage tracing demonstrated that stable methylation patterns are less tied to transient differentiation states.
What is Lorem Ipsum?
What is Lorem Ipsum?
Tumor Classification & Clonal Subtyping
- Combining somatic mutation profiles (DNA) with transcriptional signatures (RNA) allows more precise stratification of cancers
Identifying Driver Mutations & Pathway Dysregulation
- DNA reveals recurrent driver mutations, and RNA shows their influence on regulatory pathways
Predicting Therapy Response
- RNA analysis can reveal alternative splicing, pathway rewiring, or activation of bypass signaling
What is Lorem Ipsum?
Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book.
- dummy text of the printing and typesetting industry
- dummy text of the printing and typesetting industry
- dummy text of the printing and typesetting industry
- dummy text of the printing and typesetting industry
featured card
What is Lorem Ipsum?
Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book.
What is Lorem Ipsum?
Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book.
What is Lorem Ipsum?
What is Lorem Ipsum?
Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book.
What is Lorem Ipsum?
Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book.
Figure 1. Linear evolution.
Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book.
Figure 1. Linear evolution.
Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book.
What is Lorem Ipsum?
Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book.
What is Lorem Ipsum?
Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book.
What is Lorem Ipsum?
Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book.
What is Lorem Ipsum?
Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book.
What is Lorem Ipsum?
Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book.
What is Lorem Ipsum?
Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book.
What is Lorem Ipsum?
What is Lorem Ipsum?
What is Lorem Ipsum?
What is Lorem Ipsum?
What is Lorem Ipsum?
What is Lorem Ipsum?
Step 1
CELL ENCAPSULATION
CELL ENCAPSULATION
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CELL ENCAPSULATION
CELL ENCAPSULATION
What is Lorem Ipsum?
CELL ENCAPSULATION
CELL ENCAPSULATION
CELL ENCAPSULATION
What is Lorem Ipsum?
CELL ENCAPSULATION
CELL ENCAPSULATION
What is Lorem Ipsum?
CELL ENCAPSULATION
Investors
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