Single-cell genomics provides new insights into the heterogeneity of CLL

Dr. Braggio from the Mayo Clinic in Arizona gave a talk at the AACR 2019 meeting, where he looked at several patients with chronic lymphocytic leukemia (CLL) that had complex parallel mutations using single-cell technology. Utilizing Mission Bio's CLL panel that targets 32 genes implicated in CLL, he discovered diverse mutations underlying the same disease, and he reconstructed the clonality underlying each sample. Moreover, looking at a timecourse series, he showed how the clones expanded and contracted over time. He continues to touch on the patterns and data mapping provided by the Tapestri Platform and how they illuminated mutations that bulk sequencing had previously missed.