Identifying copy number variations (CNV) in single cells for breast cancer research

Tapestri Solution for Solid Tumor Research provides the resolution required to profile thousands of individual cells or nuclei, enabling a much richer characterization of tumor heterogeneity and clonality. Some key takeaways from this application note include:

• Mission Bio’s Nuclei Extraction Protocol works effectively for fresh frozen breast cancer samples and can generate high-quality single-cell DNA data.

• Tapestri Single-cell DNA Breast Cancer Research Panel V2, validated by world class key opinion leaders, including our inaugural Center of Excellence for Solid Tumor.

• The Tapestri Platform, combined with the new Tapestri Single-cell CNV Analysis Tool, enables co-measurement of single-cell SNVs and CNVs across thousands of single cells.